The Mary Frances Reger-Wilkinson papers date from 1942 to 2002 and measure 5 linear inches. The papers are organized into two series: General and World War II.

The Geneal series contains herautobiographical essay that she wrote in 2002, a 1983 article about Reger-Wilkinson from California Senior Citizen and obituaries for Reger-Wilkinson's brother and sister-in-law, Charles Kenneth Reger and Marjorie Frazier Reger. The American Red Cross folder contains general information about the organization that Reger-Wilkinson collected between 1945 and 1997, including newspaper articles, brochures and The Red Cross Courier. Also included are two small plaques Reger-Wilkinson received in appreciation for her service to The American Red Cross.

Camp Callan is a separate folder in the General series that Reger-Wilkinson labeled and organized before donating her papers. It contains issues of The Range Finder, the Camp Callan newspaper, and other articles regarding activities at Camp Callan during Reger-Wilkinson's tenure there. Reger-Wilkinson is featured in several of the newspaper articles. Of special note is the program and an article regarding the memorial service the camp held following President Franklin Roosevelt's death.

The Correspondence folder in the General series contains two items from the University of Iowa. One is a 1942 letter written to Reger-Wilkinson at Camp Haan by the head of the home economics department, Sybil Woodruff. Newspaper clippings and articles contains items that Reger-Wilkinson saved, mostly pertaining to World War II veterans and women in war.

Photographs consists of both personal and occupational photographs taken during World War II. There are several of Reger-Wilkinson and her brother Charles Kenneth "Kenny" Reger, and Reger-Wilkinson with other family members and friends. The only photograph of Bernard Wilkinson, Reger-Wilkinson's husband, was taken at their residence following the end of the war. Apparently Reger-Wilkinson took the photograph herself. Many of the photographs are of American Red Cross staff and volunteers Reger-Wilkinson worked with at the various camps where she was stationed.

Artifacts include American Red Cross buttons, badges and pins and Reger-Wilkinson's dog tags.

The bulk of the Reger-Wilkinson papers consists of her World War II diary and scrapbook. In later life, Reger-Wilkinson would regret that she did not keep a detailed journal during the war years, however she did maintain a minimal record of her days in a diary titled "My Life in the Service," that was clearly designed for a male soldier. She also saved newspaper articles and photographs. From the 1970s through the 1990s, Reger-Wilkinson recounted her experiences during World War II in a series of essays and short reminiscences. She combined these essays with the photographs and newspaper articles to create a scrapbook, "World War II--Mary Frances (Reger) Wilkinson and the American National Red Cross-Military and Naval Welfare." Because of its fragile condition, the scrapbook was photocopied and photographs and artifacts were placed in separate folders. The original pages of the scrapbook are in ten folders that follow Reger-Wilkinson's original order. The photocopied scrapbook, the photographs, and the artifacts follow. Of particular interest is information about the hospital program Reger-Wilkinson designed in her capacity as assistant field director with the American Red Cross, her memory of visiting a Japanese internment camp, descriptions of both her trip from Iowa City, Iowa to Los Angeles California via train and her husband Bernard Wilkinson's same trip via automobile on Route 66, and the final narrative report Reger-Wilkinson wrote upon dismantling Camp Callan in 1945.