The Lois Wescott papers date from the 1860s to 2001 and measure 10 linear inches. They are arranged in five series: Biographical, Family, Canyon Pointe Chronicle, Slides, and Photographs.

The Biographical series includes Wescott's baby book, which mentions the family's bout with influenza in 1918; Wescott's seventh grade report on transportation; a book on flowers Wescott used while teaching school; and a reference spelling book Wescott used while editing the journal for the School of the Mines in Colorado. The "General" folder contains notes written by Wescott's daughter, Thyria Kathleen Wilson, which describe Wescott's life and provide details on some of the items in the collection; an article about the Atlantic Refining Company published in 1947 in The Atlantic Magazine, which includes a photo and short profile of Wescott; a banner given to Wescott upon her retirement from the National Atmospheric and Oceanic Agency in 1980; and Wescott's 1928 American Red Cross swimming badges.

The Family series includes correspondence between members of the Wescott family including Lois Wescott, her sister Gwendolyn, her mother Geneva, her brother Eugene, and her maternal grandmother Ada Mae Wescott. In addition, the series includes family histories and memoirs written by Lois Wescott and her sister Gwendolyn.

The Canyon Pointe Chronicle series contains thirteen years of Canyon Pointe Chronicle newsletter, which Lois Wescott edited following her retirement. The Slides and Photographs series document Wescott's work and travel in California, Colorado, Venezuela, and Japan. Nineteenth-century photographs of Wescott's family in Hampton complete the collection.