The Louise Liers papers date from 1911 to 1983 and measure 5 linear inches. The bulk of the collection pertains to Liers' experiences in World War I. The biographical information includes an oral history interview conducted with Liers by Louis Ehrhardt in the 1970s in which Liers describes her wartime experiences; it also contains newspaper clippings about Liers written when she retired and on her 90th birthday. Liers' journal, which she kept while in France, contains just a few entries.

Liers glued many documents into a volume titled Our Family Service Record in the Great World War, published by the War Service Record Bureau to provide "a practical means of preserving the individual War Records of the gallant Sons of this great Republic." These documents include correspondence from the base hospital and the Red Cross, military passes, and a metro map of Paris. Loose documents were removed from the volume and placed in a separate folder. These include Liers' official military orders, demobilization papers, memorabilia related to social events, personal and official correspondence, and welcome home telegrams.

The correspondence album contains letters written by Liers to family members during her World War I service; most are handwritten, but a few are typed. The correspondence album also contains Liers' War Department ID, her Red Cross certification, a photograph of nurses marching in a parade, a medal attached to a multi-colored ribbon with the word "France" on it, and two letters written by Liers in the late 1970s. An album of photographs taken while Liers was stationed in France completes the collection; Liers provides details on where and why these photos were taken in her oral history interview.