This book is also designated PNSI #22.Lobelia (Lobelia inflata), also called Indian tobacco, has a long history of use as an herbal remedy for respiratory conditions such as asthma, bronchitis, pneumonia, and cough. Historically, Native Americans smoked lobelia as a treatment for asthma. In the 19th century, American physicians prescribed lobelia to cause vomiting in order remove toxins from the body. Because of this, it earned the name "puke weed." Today, lobelia is sometimes suggested to help clear mucus from the respiratory tract, including the throat, lungs, and bronchial tubes. Although few studies have evaluated the safety and effectiveness of lobelia, some herbalists today use lobelia as part of a comprehensive treatment plan for asthma. An active ingredient in the lobelia plant, lobeline, was thought to be similar to nicotine in its effect on the body. For this reason, lobeline was once used as a nicotine substitute in many anti-smoking products and preparations designed to break the smoking habit. In 1993, the U.S. Food and Drug Administration (FDA) prohibited the sale of lobeline-containing smoking products. The FDA reported that such products were not effective in helping people quit or reduce smoking. Researchers now think that lobeline may actually reduce the effects of nicotine in the body, particularly the release of dopamine. Dopamine is a brain chemical that plays a number of important roles in the brain. It is also involved in drug addiction, so researchers think that lobeline may have some potential in treating addiction. So far, however, there have been no studies to determine whether lobeline is effective. Lobelia is a potentially toxic herb. It can be safely used in small doses (particularly homeopathic doses), but moderate-to-large doses may cause side effects ranging from dry mouth and nausea to convulsions. -- Source of annotation: Marvin or Ruth Sackner. https://aspace.lib.uiowa.edu/repositories/5/archival_objects/891932 Accessed February 12, 2025.